Study of neuroprotective effects of green tea antioxidant on spinal cord injury of rat
Journal of Iranian Anatomical Sciences. 2010; 7 (28-29): 145-152
em Inglês, Persa
| IMEMR
| ID: emr-98878
ABSTRACT
Recent studies revealed the neuroprotective effects of green tea antioxidant on experimental cerebral ischemia, but these effects on spinal cord injury [SCI] has not yet been studied. Rats were randomly divided into three groups of 18 rats each as follows sham group [laminectomy], control group [SCI] and experimental group [EGCG]. Spinal cord samples were taken 24 h after injury and studied for determination of lipid peroxidation levels and TUNEL reaction. Behavioral testing was performed weekly upto six weeks post-injury. Then, the rats were euthanized for histopathological assessment. The results showed that lipid peroxidation levels were significantly decreased in experimental group. EGCG significantly reduced TUNEL-positive rate. Also, EGCG reduced significantly lesion area, and improved behavioral function more than the control group. EGCG treatment decreased secondary spinal cord injury
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ratos
/
Chá
/
Imuno-Histoquímica
/
Peroxidação de Lipídeos
/
Catequina
/
Fármacos Neuroprotetores
/
Antioxidantes
Limite:
Animais
Idioma:
Inglês
/
Persa
Revista:
J. Iran. Anat. Sci.
Ano de publicação:
2010
Similares
MEDLINE
...
LILACS
LIS