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Graves opthalmopathy and psychoendocrinopathies
MEAJO-Middle East African Journal of Ophthalmology. 2010; 17 (2): 169-174
em Inglês | IMEMR | ID: emr-98941
ABSTRACT
To assess the psychiatric and endocrinological changes in patients with Graves ophthalmopathy [GO]. A prospective, controlled, University Hospital based study. The current study comprised 60 patients diagnosed with GO at Mansoura Ophthalmic Center. Thirty five patients of them with moderate to severe GO formed the study group and twenty five patients with negligible to very mild GO formed the control group in the euthyroid state. The study group was further subdivided based on their predominant clinical signs into a proptosis subgroup and a muscle restriction subgroup. Psychiatric changes were assessed with the Middlesex Hospital Questionnaire [MHQ]. Biochemical analyses included serum-free thyroxine and thyroid-stimulating hormone [TSH] concentrations, TSH receptor antibody [TRAb] activity and antrthyroglobulin particle agglutination [TGPA] and antithyroid microsomal particle agglutination [MCPA]. The proptosis group reported significantly higher scores on anxiety, depression, and phobia than the muscle restriction group [P<0.0001]. The proptosis and muscle restriction subgroups reported significantly higher scores on all subscales compared to the control group [P<0.05]. The scale scores of depression and phobia showed a positive correlation with scores of anxiety [P<0.0001]. The serum TRAb activity showed a significant correlation with anxiety, phobia and hysteria [P<0.0001]. The psychiatric aspect of GO should be evaluated during routine follow-up and should be considered when making management decisions. Thyroid specific antibodies may be useful in confirming the diagnosis of GO
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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Ansiedade / Testes de Função Tireóidea / Exoftalmia / Estudos Prospectivos / Depressão / Oftalmopatia de Graves Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Middle East Afr. J. Ophthalmol. Ano de publicação: 2010

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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Ansiedade / Testes de Função Tireóidea / Exoftalmia / Estudos Prospectivos / Depressão / Oftalmopatia de Graves Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Middle East Afr. J. Ophthalmol. Ano de publicação: 2010