investigation of the relationship between serum vitamin e status and coronary risk factors in dyslipidaemic patients

ABSTRACT

Vitamin E is a major lipid-soluble antioxidant. It has been demonstrated that vitamin E supplementation has a beneficial effect against coronary heart disease [CHD]. This study to investigate the effects of coronary risk factors on serum vitamin E status in patients with dyslipidaemia. This tertiary care hospital; case - control study was comprised 237 dyslipidaemic patients and 135 healthy individuals recruited from university and hospital employees. Serum vitamin E concentration was measured using high performance liquid chromatography [HPLC]. Compared to the healthy individuals, the dyslipidaemic patients had higher serum vitamin E [p<0.001], but serum vitamin E / total cholesterol ratio did not differ between patients and healthy controls [p>0.05]. Serum vitamin E did not differ between subcategories of dyslipidaemic patients with and without coronary risk factors [p>0.05], but Serum vitamin E / total cholesterol ratio was higher in patients with established coronary heart disease [p<0.01], hypertriglyceridaemia [p<0.05] and metabolic syndrome [p<0.05]. In the patients there was not a strong association between serum vitamin E or serum vitamin E / total cholesterol ratio and coronary risk factors except for the serum cholesterol. Serum vitamin E or vitamin E / total cholesterol ratio is not associated with the risk of coronary heartdisease. Therefore, higher serum vitamin E or vitamin E / total cholesterol ratio doesn't seern to have a preventive role against coronary heart disease