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Apoptosis suppressing protein Bcl-2 expression in rheumatoid synovium
Bulletin of Alexandria Faculty of Medicine. 2008; 44 (4): 829-832
em Inglês | IMEMR | ID: emr-99566
ABSTRACT
It has been suggested that defective apoptosis plays a role in the development of autoimmune. The aim of this study is to investigate the apoptosis suppressing protein Bcl-2 in the rheumatoid synovum. Twenty synovium biopsy specimens were studied histopathologically and immuno-histochemically. Positive immunoreactivity was observed in 16 cases [80%] the infiltrated lymphocytes and in 11 cases [55%] in the lymphoid follicles, while, in 8 cases [40%] deep synovial fibroblasts showed marked Bcl-2 positively. The superficial synovial cell lining was only positive in 5 cases [25%].The apoptotic process is suppressed in rheumatoid arthritis as triggered by Bcl-2 oncoprotein. The defective control of apoptosis. [programmed cell death] as well excessive proliferation may he of central importance in the pathogenesis of rheumatoid arthritis
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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Artrite Reumatoide / Membrana Sinovial / Biópsia / Imuno-Histoquímica / Proteína Killer-Antagonista Homóloga a bcl-2 Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Bull. Alex. Fac. Med. Ano de publicação: 2008

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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Artrite Reumatoide / Membrana Sinovial / Biópsia / Imuno-Histoquímica / Proteína Killer-Antagonista Homóloga a bcl-2 Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Bull. Alex. Fac. Med. Ano de publicação: 2008