Estimation of trace elements level in chronic renal diseases

ABSTRACT

Trace elements are essential nutrients with an extent of functions. They are indispensable components of many enzymes confer regulatory functions and affect the immune reactions and the free radical generation. The aim of this study is to estimate the serum level of copper, zinc and lead in patients with chronic kidney diseases. As well to clarify the impact of the renal disease and hemodialysis therapy on trace elements levels compared to healthy subjects. This study included sixty subjects with age ranged from 45 to 68 years, divided into three groups. The First [group-1] consisted of 20 patients with chronic kidney disease not performing hemodialysis. The second [group-2] were 20 patients with chronic kidney failure undergoing hemodialysis. The third [group-3] were 20 apparently healthy subjects as a control group. Serum copper, zinc and lead were estimated using atomic absorption spectrophotometry. A significant increase in serum lead observed in group-2 compared to group-3. Besides, there were significant decreases in serum zinc in group-1 and group-2 as compared to group-3. Disturbances in the zinc and lead metal status investigated in CRD and hemodialysis patients than normal subjects which require early management