Protective effect of Zuroor-e-Qula' against gastric mucosal damage: an ultrastructural study

ABSTRACT

The gastro-protective activity of the PHF [Zuroor-e-qula'] and its extracts was assessed in three different models of experimentally induced gastric ulcers in rats. In case of both preventive and curative treatments at 400 mg/kg dose the PHF and the aqueous and alcoholic extracts reduced gastric lesions significantly which were induced by HCl/ethanol. Significant changes in gastric parameters such as pH, volume of gastric juice and gastric acidity after oral administration of the samples under ligated pylorus [Shay] conditions. Also, in this paper, we report the ultrastructural observations of gastric mucosa. The ultrastructural changes were observed by Scanning Electron Microscopy [SEM]. The preventive as well as curative treatments in rats revealed a protective action against HCl/ethanol induced gastric mucosal damage. Probably, polyphenols, flavonoids, essential and fixed oils of the formulation were involved