Systemic humoral Anti Helicobacter pylori immune response in dyspeptic patients

ABSTRACT

Helicobacter pylori [HP] cause a continuous gastric inflammation virtually all infected persons. It induces a vigorous systemic and mucosal humoral and cellular immune response. In spite of these responses, the vast majority of infected hosts are unable to clear the infection and it persists for decades. Determination the humoral immune response to HP infection in dyspeptic patients. The immunological serological tests were evaluated in 80 dyspeptic patients divided into two groups [HP +] and [HP-]. Levels of specific HP IgG antibodies were determined through a specific immunological non invasive Enzyme Linked Immuno Sorbent Assay [ELISA] test from Biohit PIC, Helsinki, Finland. Immunoglobulin levels and complement were done [IgG, IgA, IgM, C3 and C4] using single radial immune diffusion [BioMaghreb-Tunis]. About 62.5% of dyspeptic patients had HP + infection. There was no significant differences between two groups in the levels of [IgG, IgA, IgM, C3 and C4] and most of them were within normal values. Humoral immune response had an important role in the control and limits the inflammation of gastric mucosa