Arterial atherosclerosis in patients with chronic kidney disease and its relationship with serum and tissue
IJKD-Iranian Journal of Kidney Diseases. 2009; 3 (4): 203-209
em Inglês
| IMEMR
| ID: emr-99966
ABSTRACT
We investigated the correlation between atherosclerosis and tissue and serum levels of endothelin-1 in patients with chronic kidney disease [CKD]. Arterial samples were obtained from 35 patients with CKD during arteriovenous fistula placement. Thirty-one patients with cardiovascular disease who underwent coronary artery bypass graft [CABG] were selected as the atherosclerotic group, and a piece of their aorta punched during CABG was obtained. Also, a small piece of the renal artery was dissected during donation in 24 kidney donors [control group]. Tissue endothelin-1 level was measured and atherosclerosis grading was determined by pathologic examination. Serum levels of endothelin-1 were also measured in the three groups. The mean tissue endothelin-1 levels were 10.73 +/- 7.57 pg/ mL, 12.16 +/- 3.95 pg/mL, and 0.93 +/- 1.06 pg/mL in the patients with CKD, those with CABG, and donors, respectively [P < .001]. The mean serum endothelin-1 level was 25.23 +/- 15.15 pg/mL in the patients with CKD, 21.13 +/- 17.22 pg/mL in the patients with CABG, and 2.66 +/- 1.51 pg/mL in the donors [P < .001]. Atherosclerosis grades correlated with tissue endothelin-1 level [r = 0.823, P < .001] and serum endothelin-1 level [r = 0.608, P < .001] in the patients with CKD. Multiple regression analysis showed tissue endothelin-1 level as the main predicting factor of atherosclerosis [P < .001]. Tissue endothelin-1 concentration is more important than serum endothelin-1 or lipids levels in prediction of atherosclerosis. Thus, blockade of tissue endothelin-1 receptors with its antagonists may prevent atherosclerosis progression
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Doadores de Tecidos
/
Biópsia
/
Ponte de Artéria Coronária
/
Receptores de Endotelina
/
Endotelina-1
/
Doadores Vivos
/
Falência Renal Crônica
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Iran. J. Kidney Dis.
Ano de publicação:
2009
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