Inhibition of macrophage phagocytosis of Escherichia coli by mannose and mannan
Braz. j. med. biol. res
;
24(9): 919-24, Sept. 1991. tab
Artigo
em Inglês
| LILACS
| ID: lil-102099
ABSTRACT
1. We investigated the possibility that Candida albicans and Escherichia coli are interiorized by thioglycollate-elicited peritoneal macrophages by interacting with the same receptor. 2. D-mannose (50 mM), a sugar recognized by mannose receptors, reduced the phatfocytosis of C. albicans and E. coli to 46% and 38% of control values, respectively. The presence of 50 mM galactose did not affect the phagocytosis of either microorganism. However, mannan from saccharomyces cerevisiae (0.5 mg/ml) inhibited phagocytosis by 70% for both microorganisms. 3. The ingestion of C. albicans and E. coli was reduced by 85% and 95%, respectively, in the presence of 10 mM EGTA. 4. These results suggest that the mannose receptor, which mediates the recognition of C. albicans by macrophages, might also mediate the phagocytosis of Escherichia coli 0111
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Índice:
LILACS (Américas)
Assunto principal:
Fagocitose
/
Candida albicans
/
Escherichia coli
/
Macrófagos
/
Mananas
/
Manose
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1991
Tipo de documento:
Artigo
/
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