Neuroleptic malignant syndrome among acute psychiatric admissions in Barbados
West Indian med. j
;
41(1): 15-8, Mar. 1992.
Artigo
em Inglês
| LILACS
| ID: lil-107503
ABSTRACT
The main features of the Neuroleptic Malignant Syndrome (NMS), a complication of neuroleptic therapy, are fever, muscle rigidity, autonomic dysfunction, and an alteration in consciousness level. We describe five cases of NMS comprising 0.6 per cent of acute neuroleptically-treated admissions to a psychiatric hospital over a one-year period. All patients, four females aged 26 to 63 years, and one male, aged 65 years, were of African origin and received multiple neuroleptic drugs, at least one of which was a depot preparation. Four were being treated for functional psychiatric disorders while one had dementia. All patients had fever and depressed consciousness level while four had rigidity and autonomic dysfunction. Serum creatine phosphokinase was elevated in 4 cases, and there was indirect evidence of myoglobinuria in 3 cases suggested by a positive urine dipstick test for blood despite the absence of red cells on microscopy. Rhabdomyolysis was associated with renal failure in one case. Both bromocriptine mesylate and dantrolene sodium were given in two cases. Three patients died in hospital, one with persistent rigidity and progressive decubitus ulceration, one from peritonitis following dialysis, and another suddenly. Early recognition of NMS is important; it should be considered in any patient on neuroleptic therapy who develops fever, rigidity or alteration in consciousness level.
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Índice:
LILACS (Américas)
Assunto principal:
Antipsicóticos
/
Síndrome Maligna Neuroléptica
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Fatores de risco
País/Região como assunto:
Barbados
/
Caribe Inglês
Idioma:
Inglês
Revista:
West Indian med. j
Assunto da revista:
Medicina
Ano de publicação:
1992
Tipo de documento:
Artigo
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