Effect of propranolol and nifedipine on in vitro fluid absorption by the isolated perfused proximal convoluted tubule of the rabbit
Braz. j. med. biol. res
;
24(12): 1265-8, 1991. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-113308
ABSTRACT
The inhibition of fluid absorption (Jv) by the antiarrhythmic and antihypertensive drugs propranolol and nifedipine, which increase cytosolic Ca*+ concentration, was studied using the isolated rabbid proximal convoluted tubule perfused in vitro. Proximal convuluted tubules were perfused and bathed with a modified Krebs-Henseleit solution containing bovine serum albumin. Jv was measured after a 30-min control period, after 40 min with eithe 0.1 mM propranolol or 1.0 mM mifedipine on the peritubular side and after a 40-min recovery period. Both drugs inhibited Jv (58% propranolol, and 21% nifedipine) The 40-min recovery period was sufficient to reserve the effect of nifedipine, but propranolol-treated tubules (N=6) only reached 78% of the control Jv value. These results demonstrate that antiarrhythmic and anthypertensive drugs are powerful inhbitors of net fluid absorption by exerting a direct effect on proximal or distal tubule cells, thus acting like "local diuretics"
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Índice:
LILACS (Américas)
Assunto principal:
Propranolol
/
Técnicas In Vitro
/
Nifedipino
/
Túbulos Renais Proximais
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1991
Tipo de documento:
Artigo
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