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Further studies on the hypoxia produced by canatoxin in rats
Braz. j. med. biol. res ; 25(8): 849-52, 1992. tab
Artigo em Inglês | LILACS | ID: lil-113581
RESUMO
Canatoxin, a convulsant neurotoxin from the seeds of Canavalia ensiformis, induces lipoxygenase-dependent hypoxia in rats which is blocked by hexamethonium. The purpose of the present study was to examine the relationship between canatoxin-induced hypoxia and bronchoconstriction. Since several effects of the toxin are very similar to those described for morphine and opioid-like peptides, the effects of opioid antagonists were also investigated. Pretreatment of male, adult Wistar rats (200-250 g) with cyproheptadine (80 ug/kg, ip, N=6) and isoproterenol (100 ug/kg, ip, N+6) partially blocked (% variation of pO2CNTX alone -26.67 ñ 2.56, N=6; with cyproheptadine 16.15 ñ 2.97*, N=6; with isoproterenol 17.73 ñ 1.93*, N=6; *P<0.05 as compared to CNTX alone) the hypoxia but no effect was observed with diphenhydramine (2 mg/kg, ip, N=6) or atrophine (2 mg/kg, ip, N=6). The hypoxemic effect of canatoxin (100 ug/kg iv 20 min, N=6) was also almost completely blocked with either naloxone (1 mg/kg, sc, N=6) or naltrexone (5 mg/kg, sc, N=6). The results presented here provide evidence suggesting that both opioid peptides and bronchoconstriction seem to play a role in the hypoxia caused by canatoxin
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Índice: LILACS (Américas) Assunto principal: Ópio / Brônquios / Lipoxigenase / Constrição / Convulsivantes / Hipóxia Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 1992 Tipo de documento: Artigo

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Índice: LILACS (Américas) Assunto principal: Ópio / Brônquios / Lipoxigenase / Constrição / Convulsivantes / Hipóxia Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 1992 Tipo de documento: Artigo