Modeling AIDS vaccines: the cellular level
Mem. Inst. Oswaldo Cruz
; 87(1): 103-13, jan.-mar. 1992. tab, ilus
Article
em En
| LILACS
| ID: lil-116290
Biblioteca responsável:
BR15.1
RESUMO
This paper discuses current strategies for the development of AIDS vaccines wich allow immunzation to disturb the natural course of HIV at different detailed stages of its life cycle. Mathematical models describing the main biological phenomena (i.e. virus and vaccine induced T4 cell growth; virus and vaccine induced activation latently infected T4 cells; incremental changes immune response as infection progress; antibody dependent enhancement and neutralization of infection) and allowing for different vaccination strategies serve as a backgroud for computer simulations. The mathematical models reproduce updated information on the behavior of immune cells, antibody concentrations and free viruses. The results point to some controversial outcomes of an AIDS vaccine such as an early increase in virus concentration among vaccinated when compared to nonvaccinated individuals
Texto completo:
1
Índice:
LILACS
Assunto principal:
Vacinas Virais
/
Síndrome da Imunodeficiência Adquirida
/
HIV
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
1992
Tipo de documento:
Article