Characterization of a Plasmodium falciparum mutant that has deleted the majority of the gametocyte-specific Pf11-1 locus
Mem. Inst. Oswaldo Cruz
;
87(supl.3): 91-4, 1992. tab, ilus
Artigo
em Inglês
| LILACS
| ID: lil-121081
ABSTRACT
We identified a gametocyte-specific protein of Plasmodium falciparum called Pf11-1 and provide experimental evidence that this molecule is involved in the emergence of gametes of the infected erythrocyte (gametogenesis). A mutant parasite clone, which has deleted over 90% of the PF11-1 gene locus, was an important control to establish the gametocyte-specific expression of the Pf11-1. Molecular analysis of the Pf11-1 deletion indicates that it is presumably due a chromosome breakage with subsequent "healing" by the addition of telomeric heptanucleotides. Moreover, similar DNA rearrangements are observed in most of the laboratory isolates during asexual propagation in vitro
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Plasmodium falciparum
/
Deleção Cromossômica
/
Antígenos de Histocompatibilidade
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1992
Tipo de documento:
Artigo
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