Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria
Mem. Inst. Oswaldo Cruz
;
87(supl.3): 443-7, 1992. tab
Artigo
em Inglês
| LILACS
| ID: lil-121143
RESUMO
Although several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parazitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This similar to the findings een in human cerebral malaria. Crebral microvessels with sequestred PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Plasmodium
/
Cérebro
/
Macaca mulatta
/
Malária
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1992
Tipo de documento:
Artigo
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