Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages
Mem. Inst. Oswaldo Cruz
;
85(4): 401-5, Oct.-Dec. 1990. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-127776
RESUMO
Single doses of drugs active aginst Trypanosoma cruzi (megazol, nifurtimox and benznidazole) induce a rapid clearence of the blood parasites in experimentally infected mice. Furthermore, the in vitro phagocytosis and intracellular destruction by mouse peritoneal macrophage of blood forms collected from the treatment animals is strongly enhanced as compared with parasites from untreated controls. The uptake of the blood forms by macrophages is significantly higher with megazol than with benznidazole and nifurtimox, a finding that concurs with data showing that megazol is also the most active compound in the living host. The possibility that macrophages participate in a synergic effect between the host immune response and chemotherapeutic effect is discussed
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Tripanossomicidas
/
Trypanosoma cruzi
/
Técnicas In Vitro
/
Doença de Chagas
/
Macrófagos
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1990
Tipo de documento:
Artigo
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