Physiological, biochemical and molecular mechanisms of salt appetite control by mineralocorticoid action in brain
Braz. j. med. biol. res
;
25(12): 1153-62, 1992. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-134494
RESUMO
Adrenocortical hormone effects in the central nervous system depend on steroid interaction with intracellular receptors, which belong to a superfamily of ligand-activated transcription factors. Using a combination of biochemical and molecular biology techniques, we have demonstrated: 1. the localization of mineralocorticoid receptors in the brain, with highest density present in hippocampus, lateral septum and some amygdaloid nuclei; 2. the arousal of a mineralocorticoid-specific behavior such as salt appetite, coincident with inhibition of the biosynthesis/activity of (Na+K)ATPase in some amygdaloid and hypothalamic nuclei; 3. the modulation of the biosynthesis/activity of the sodium pump by glucocorticoids, although for these hormones changes are stimulatory, as shown in the spinal cord and brain; 4. the reported steroid effects on the (Na+K)ATPase constitute an important mechanism of control of nervous system function, involving behavior, changes in excitability and neurotropism
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Índice:
LILACS (Américas)
Assunto principal:
Regulação do Apetite
/
Encéfalo
/
Cloreto de Sódio na Dieta
/
Mineralocorticoides
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1992
Tipo de documento:
Artigo
/
Congresso e conferência
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