Effects of cyclosporin A immunosuppression on pancreaticoduodenal transplantation in alloxan-diabetic rats
Braz. j. med. biol. res
;
25(12): 1185-95, 1992. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-134497
ABSTRACT
1. Forty-five outbred Wistar rats were randomly assigned to three experimental groups GI, 10 non-diabetic control rats; GII, 10 alloxan-diabetic control rats; GIII, 25 alloxan-diabetic rats which received pancreaticoduodenal transplantation (PDT) from normal Wistar donor rats and were immunosuppressed with cyclosporin A (Cy-A), 10 mg kg body weight-1 day-1, administered intraperitoneally for 30 days. 2. In parallel, 15 alloxan-diabetic inbred Wistar rats received isogeneic PDT from normal Wistar donor rats. 3. Cy-A prevented graft rejection in the 15 surviving animals in group III. These observations were confirmed by clinical and biochemical parameters (body weight, urine output, water and food intake, blood and urinary glucose and plasma insulin) and by histology and immunohistochemistry of the pancreas. 4. However, Cy-A was associated with 60% of the infectious complications in transplanted rats leading to 40% mortality. Pulmonary infections were the main cause of death. There were no side effects of immunosuppression on the pancreas. Infections were not significant in inbred rats submitted to PDT
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LILACS (Américas)
Assunto principal:
Transplante das Ilhotas Pancreáticas
/
Terapia de Imunossupressão
/
Ciclosporina
/
Diabetes Mellitus Experimental
/
Duodeno
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1992
Tipo de documento:
Artigo
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