Experimental coccidioidomycosis in the immunosuppressed rat
Rev. Inst. Med. Trop. Säo Paulo
;
34(4): 303-7, jul.-ago. 1992. tab
Artigo
em Inglês
| LILACS
| ID: lil-134521
RESUMO
C. immitis inoculated rats are known to develop infection restricted to lung whereas cyclophosphamide (CY) treatment leads to widespread dissemination with considerable mortality. In this study, an attempt was made to elucidate the mechanisms involved in such behaviour. With this aim, spleen cells were transferred from infected CY-treated to infected untreated rats, achieving significant specific inhibition in footpad swelling to coccidioidin in recipients, attributable to a suppressor T cell subpopulation induced by greater fungal antigen concentration arising from widespread C. immitis dissemination in immunosuppressed animals. NK activity proved similar regardless of CY treatment. Lastly, chronically infected rats presented increased colony forming units count after several weekly doses of CY, as happens in immunosuppressed patients harbouring a previous infection
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hospedeiro Imunocomprometido
/
Coccidioidomicose
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Assunto da revista:
Medicina Tropical
Ano de publicação:
1992
Tipo de documento:
Artigo
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