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Immune response in mice immunized with acidic antigenic fractions from Trypanosoma cruzi cytosol
Rev. Inst. Med. Trop. Säo Paulo ; 34(5): 389-94, set.-out. 1992. ilus, graf
Artigo em Inglês | LILACS | ID: lil-134535
RESUMO
The humoral and cellular immune responses as well as the resistance to infection with bloodstream forms of T. cruzi were studied in mice immunized with acidic antigenic fractions from parasite cytosol, F III and F IV, plus Bordetella pertussis as adjuvant. The immunization with F III induced positive ITH and DTH responses to homologous antigens. In mice immunized with F IV, the ITH was negative and four out of six animals presented positive DTH reactions. In both groups of mice the analysis of IgG against T. cruzi showed that the major isotype elicited was IgG1. Specific IgE was also detected in sera from F III immunized mice, thus confirming the presence of homocytotropic antibodies. The parasitemias reached by F III and F IV immunized mice after challenge were lower than those of the controls showing in this way a partial protection against the acute infection. The histological studies of heart and skeletal muscle performed two months after the infection revealed variable mononuclear infiltration in all infected mice despite immunization
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Trypanosoma cruzi / Imunização / Citosol / Reações Antígeno-Anticorpo / Antígenos de Protozoários Limite: Animais Idioma: Inglês Revista: Rev. Inst. Med. Trop. Säo Paulo Assunto da revista: Medicina Tropical Ano de publicação: 1992 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Trypanosoma cruzi / Imunização / Citosol / Reações Antígeno-Anticorpo / Antígenos de Protozoários Limite: Animais Idioma: Inglês Revista: Rev. Inst. Med. Trop. Säo Paulo Assunto da revista: Medicina Tropical Ano de publicação: 1992 Tipo de documento: Artigo