Un nuevo sustrato para la deteccón de anticuerpos antimicondriales en suero humano / A new substrate for detection of antimitochondrial antibodies in human serum
Rev. méd. Chile
;
122(8): 889-99, ago. 1994. tab, ilus
Artigo
em Espanhol
| LILACS
| ID: lil-137952
RESUMO
This work describes a new model to detect antimitochondrial antibodies using indirect immunofluorescence on mouse sperm as substrate. As controls conventional substrates and mitochondrial protein immunoblots were esed. An intense fluorescent reaction was visualized in the mitochondrial sheet of mouse sperms allowing a straightforward diagnosis of positive sera. Sera coming from 10 patients with progressive systemic sclerosis, 12 patients with systemic lupus erythematosus and 17 patients with primary biliary cirrhosis were tested with this method, confirming results obtained with conventional tests that use indirect immunofluorescence and rat frozen kidney slices as substrate. The new method is simpler, more accurate and has a lower margin of error
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Índice:
LILACS (Américas)
Assunto principal:
Escleroderma Sistêmico
/
Cirrose Hepática Biliar
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Estudo diagnóstico
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1994
Tipo de documento:
Artigo
/
Documento de projeto
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