Novel GPI structures of the membrane anchor of acetylcholinesterase from the electric organ of Torpedo californica
Braz. j. med. biol. res
;
27(2): 243-8, Feb. 1994. ilus
Artigo
em Inglês
| LILACS
| ID: lil-140259
ABSTRACT
The structure of the glycan moiety of the glycosylphosphatidylinositol (GPI) membrane anchor from Torpedo californica electric organ acetylcholinesterase was solved using nuclear magnetic resonance (NMR), methylation analysis, and chemical and enzymic microsequencing. Two structures were found to be present Glcalfa1-2 Manalfa1-2 Manalfa1-6 Manalfa1-4 GlcNalfa1-6myo-inositol, and Glcalfa1-2 Manalfa1-2 Manalfa1-6 (GalNAcß1-4) Manalfa1-4 GlcNalfa1-6myo-inositol. The presence of glucose in this GPI anchor structure is a novel feature. The anchor was also shown to contain 2.3 residues of ethanolamine per molecule
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Índice:
LILACS (Américas)
Assunto principal:
Fosfatidilinositóis
/
Acetilcolinesterase
/
Torpedo
/
Glicolipídeos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1994
Tipo de documento:
Artigo
/
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