The diphenhydramine-induced decrease in general open-field activity of female rats is gonadal steroid dependent
Braz. j. med. biol. res
; 26(3): 319-22, Mar. 1993. tab
Article
em En
| LILACS
| ID: lil-148695
Biblioteca responsável:
BR1.1
RESUMO
The effect of ovarian steroids on sedative effects of diphenhydramine (D), a histamine H1 receptor blocker, was determined. Seventy-five female Wistar rats were randomly divided into three groups Group 1 (N = 54) was ovariectomized, group 2 (N = 7) was sham-operated, and group 3 (N = 14) was intact. The ovariectomized rats were then subdivided into 4 groups. Two groups received peanut oil 54 and 6 h before treatment with saline solution (group OS) or 20 mg/kg D (group OD). The other two groups received 50 micrograms/kg 17-beta-estradiol and 2 mg/kg progesterone, respectively, 54 and 6h before treatment with saline solution (group OHS) or 20 mg/kg D (group OHD). The sham-operated animals were treated as the OS group. Intact animals were injected with saline (group IS) or 20 mg/kg D (group ID) on the day of estrus, as determined by vaginal smears taken in the morning before the behavioral observations. Rats were observed for 6 min in the open field during the dark period of the cycle, 15 min after the administration of saline or D. There was a similar decrease in locomotion and rearing frequencies in OHS vs OHD and IS vs ID groups. Nevertheless, a lack of D sedative effect was observed in OD rats (locomotion and rearing frequencies, 56.0 +/- 3.3 vs 46.1 +/- 3.8 and 15.5 +/- 1.6 vs 15.2 +/- 1.6., for OS and OD groups, respectively). The results suggest that the sedative effect of diphenhydramine depends on the presence of ovarian steroids
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Índice:
LILACS
Assunto principal:
Comportamento Animal
/
Difenidramina
/
Estrogênios
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1993
Tipo de documento:
Article
/
Congress and conference