Threshold determination of spreading depression evoking substances in the retina in vitro
Braz. j. med. biol. res
;
26(8): 875-7, Ago. 1993.
Artigo
em Inglês
| LILACS
| ID: lil-148760
ABSTRACT
A technique for the determination of the threshold concentrations of chemical substances for elicitation of spreading depression is described. The technique minimizes the interference of mechanical stimulating effects and alterations in the susceptibility of the retina to spreading depression due to changes in unstirred layers at the liquid-tissue interphase. The following threshold concentrations were shown to elicit the wave 8000-10000 microM KCl, 100-200 microM sodium glutamate, 5-10 microM sodium kainate, 10-20 microM sodium N-methyl-aspartate, 600-1200 microM (NH4)2SO4 and 400-600 microM BaCl2. Variations of K+ or Mg2+ concentration in the standard Ringer solution that may cause an increase or decrease of spreading depression velocity have an inverse effect on the threshold for elicitation of the reaction
Buscar no Google
Índice:
LILACS (Américas)
Assunto principal:
Retina
/
Depressão Alastrante da Atividade Elétrica Cortical
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1993
Tipo de documento:
Artigo
/
Congresso e conferência
Similares
MEDLINE
...
LILACS
LIS