Central angiotensin converting enzyme-blockade and thirst
Braz. j. med. biol. res
; 26(9): 999-1007, Sept. 1993. graf
Article
em En
| LILACS
| ID: lil-148774
Biblioteca responsável:
BR1.1
ABSTRACT
1. The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g). 2. Injection of lisinopril (2 micrograms/microliters) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100 per cent ) and water deprivation (90 per cent ) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60 per cent ). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group). 3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied
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Índice:
LILACS
Assunto principal:
Área Pré-Óptica
/
Sede
/
Inibidores da Enzima Conversora de Angiotensina
/
Ingestão de Líquidos
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1993
Tipo de documento:
Article