Mecanismos enzimáticos de resistencia a antibióticos aminoglicósidos en bacilos gram negativos de hospitales chilenos / Enzymatic mechanisms of resistance to aminoglycoside antibiotics in gram negative bacilli from chilean hospitals

ABSTRACT

The presence of aminoglycoside modifying enzyme (AMEs) has been investigated by an agar diffusion method, in 344 strains of aminoglycoside-resistant Gram negative bacilli isolated in different Chilean hospitals. Most of the strains exhibited a combination of enzymatic mechanism of resistance, but 2 acetylatting (AAC(3)II and AAC(6')I) and one phosphorylating (APH(3')I) enzymes were mechanism detected in the strains. A significant increase in the frequency of strains producing AAC(6')I), possibly due to wide use of amikacin, has been found when results were compared with those of a report published in 1985