Prostaglandin A1, inhibits replication of Mayaro virus in Aedes albopictus cells
Braz. j. med. biol. res
;
28(1): 27-30, Jan. 1995. ilus
Artigo
em Inglês
| LILACS
| ID: lil-153327
ABSTRACT
Prostaglandin A1 (PGA1) reduced Mayaro virus replication in Aedes albopictus (mosquito) cells in culture. The highest nontoxic dose of PGA1, 7.5µM, decreased virus production by 90 percent. In Mayaro virus-=infected cells, PGA1 inhibited virus-specific protein synthesis. However, in mock-infected cells the presence of PGA, stimulated the synthesis of several proteins with molecular masses of 70, 57 and 23 kDa, respectively. The data obtained from this study show that PGA1 plays a role in the metabolic regulation of Aedes albopictus cells, blocking the synthesis of Mayaro virus and inducing the synthesis of cellular polypeptides
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Índice:
LILACS (Américas)
Assunto principal:
Peptídeos
/
Prostaglandinas A
/
Proteínas Virais
/
Replicação Viral
/
Alphavirus
/
Aedes
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
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