Inhibition of enteropathogenic Escherichia coli adhesion to HeLa cells by serum of infants with diarrhea and by cord serum
Braz. j. med. biol. res
; 28(1): 83-7, Jan. 1995. graf
Article
em En
| LILACS
| ID: lil-153334
Biblioteca responsável:
BR1.1
ABSTRACT
We have studied the effect of serum from infants with diarrhea and of cord serum on the localized adherence of enteropathogenic Escherichia coli (EPEC) to HeLa cells. Serum samples from 16 infants with diarrhea due to EPEC of serotypes O55H6, O111 H-, O111H2, O119H6 and O142H6 were used. The adherence ability of EPEC strains belonging to serotypes identical to (homologous) or different from (heterologous) those isolated from the infants' feces was highly inhibited by samples of infant serum collected both during the acute phase of the illness and upon discharge from the hospital. These data confirm the development of antibodies against EPEC adhesins and the cross-reaction between different EPEC serotypes. Cord serum inhibited the localized adherence of EPEC strains at different levels according to the serotype of the strain studied. These results suggest that the placental transfer of adhesin-related antibodies does not protect the newborn against EPEC infections, since half of our patients were less than 30 days old
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Índice:
LILACS
Assunto principal:
Atividade Bactericida do Sangue
/
Aderência Bacteriana
/
Células HeLa
/
Diarreia Infantil
/
Escherichia coli
/
Sangue Fetal
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1995
Tipo de documento:
Article