Domoic acid induces neurotoxicity and ip3 mobilization in cultured cells of embryonic chick retina
Braz. j. med. biol. res
;
28(1): 100-7, Jan. 1995. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-153336
RESUMO
Domoic acid (DOM), 1 to 50 µM, a glutamate agonist responsible for several neurological effects such as loss of memory and confusion, induced the death of cultured neurons of chick embryonic retina, in a concentration- and Ca2+ -dependent manner. This effect was blocked by 100 µM CNQX, a competitive antagonist of the non-NMDA receptor, but not by 10 µM MK-801, a non-competitive antagonist of the NMDA receptor. DOM also induced inositol triphosphate (ip3) accumulation 4 to 7 times above basal levels. This effect was also dependent on external Ca2+ and was entirely blocked by 100 µM CNQX, but not by 10 µM MK-801. These results suggest that DOM interaction with non-NMDA glutamate receptors mediates signal transduction with ip3 accumulation and cell death
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Índice:
LILACS (Américas)
Assunto principal:
Retina
/
Receptores de N-Metil-D-Aspartato
/
Receptores de Ácido Caínico
/
Ácido Caínico
/
Neurônios
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
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