Studies of natural killer cells in pregnancy-induced hypertension
Braz. j. med. biol. res
;
28(6): 655-61, Jun. 1995. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-154934
ABSTRACT
The number and activity of natural killer (NK) cells were studied in 20 patients with pregnancy-induced hypertension (PIH), 15 uncomplicated pregnant women and 16 healthy non-pregnant women. All the pregnant women were evaluated during the third trimester of gestation. Peripheral blood NK cells were detected with monoclonal antibodies by indirect immunofluorescence and cytotoxic activity was measured using a single-cell assau against K562 target cells, Hypertensive pregnant women had an increased number of circulating NK cells associated with a significant decrease of NK activity. The cytotoxic activity was significantly lower in normal pregnant and PIH women when compared with non-pregnant controls. The onset of immune NK cells in peripheral blood and the impairment of their cytotoxic activity in PIH patients may be associated with hormones and immunosuppresive substances produced by tissues occurring at the maternal-fetal interface
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Índice:
LILACS (Américas)
Assunto principal:
Complicações na Gravidez
/
Células Matadoras Naturais
/
Hipertensão
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
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