Apoptosis as a cause of T-cell unresponsiveness in experimental Chagas' disease
Braz. j. med. biol. res
;
28(8): 913-8, Aug. 1995. ilus
Artigo
em Inglês
| LILACS
| ID: lil-156287
RESUMO
A murine model of Chagas'disease induced by metacyclic forms of T. cruzi was used to evaluate T-cell function during infection. T-cell unresponsiveness to TcR; CD3 stimulation in vitro and lymphocyte activation in vivo occurred simultaneously. These paradoxical findings ar discussed in the light of recent evidence that mature activated T cells become susceptible to TcR-mediated apoptosis. Activation-induced death in T cells from T. cruzi-infected mice has recently been demonstrated in this model. Evidence that TcR-induced death of activated T cells could be a cause for T-cell unresponsiveness in vitro and in vivo, as well as the possible molecular mechanisms involved, are discussed.
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Índice:
LILACS (Américas)
Assunto principal:
Técnicas In Vitro
/
Linfócitos T
/
Doença de Chagas
/
Apoptose
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
/
Congresso e conferência
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