El sistema mayor de histocompatibilidad como factor de riesgo de la enfermedad hepática alcohólica / Major histocompatibility system as a risk factor of alcoholic hepatic disease
Rev. méd. Chile
;
123(6): 687-93, jun. 1995. tab
Artigo
em Espanhol
| LILACS
| ID: lil-156937
ABSTRACT
Several associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and changes from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among chilean alcoholics. We studied blood groups, serum proteins and HLA antigens in 39 alcoholic cirrhotics, 104 asymptomatic alcoholics and 44 non alcoholic controls. Asymptomatic alcoholics were also subjected to a percutaneous liver biopsy that showed moderate to severe histological liver damage in 46 subjects (44 percent). No differences in the studied genetic markers, were found among the four groups. It is concluded that this study does not confirm previously reported associations between genetic markers and alcoholic liver disease
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Índice:
LILACS (Américas)
Assunto principal:
Cirrose Hepática Alcoólica
/
Complexo Principal de Histocompatibilidade
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
/
Documento de projeto
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