Characterization of T cell clones from chagasic patients: predominance of CD8 surface phenotype in clones from patients with pathology
Mem. Inst. Oswaldo Cruz
; 90(4): 503-6, jul.-ago. 1995. tab
Article
em En
| LILACS
| ID: lil-157301
Biblioteca responsável:
BR15.1
ABSTRACT
Human Chagas' disease, caused by the protozoan Trypanosoma cruzi, is associated with pathological processes whose mechanisms are not known. To address this question, T cell lines were developed from chronic chagasic patients peripheral blood mononuclear cells (PBMC) and cloned. These T cell clones (TCC) were analyzed phenotypically with monoclonal antibodies by the use of a fluorescence microscope. The surface phenotype of the TCC from the asymptomatic patient were predominantly CD4 positive (86 por cento). On the contrary, the surface phenotype CD8 was predominant in the TCC from the patients suffering from cardiomegaly with right bundle branch block (83 por cento), bradycardia with megacolon (75 por cento) and bradycardia (75 por cento). Future studies will be developed in order to identify the antigens eliciting these T cell subpopulations.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Trypanosoma cruzi
/
Linfócitos T CD4-Positivos
/
Doença de Chagas
/
Microscopia de Fluorescência
Limite:
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article