Tenoxicam venoso para prevençåo da dor pós-operatória em cirurgia abdominal superficial / Prevention of postoperative pain after abdominal dermoliprctomy with intravenous tenoxicam

ABSTRACT

Intravenous tenoxicam, a non-steridal anti-inflammatory drug (NSAID), was evaluated for postoperative pain relief after abdominal dermolipectomy. All patients received epidural anesthesia with 0,5 por cent bupivacaine with epinephrine 1:200,000. Twenty patients received 2 ml of saline, Group A1 (N=10) before and group A2 (n=10) after surgery. Twenty patients, Group B (N=20), received 20 mg (2 ml) of intravenous tenoxicam before the epidural , while the rest of them received the same dose after completion of surgery (Group C, N=20). Duration of postoperative analgesia, intensity of pain, supplementary analgesic requirement and adverse side effects were assessed. Patients who received tenoxicam had longer duration of postoperative analgesia (p<0,05), lower pain scores at 6 and 12 hours (p<0,01) and request less supplemental analgesics (p<0,05) compared to Group A. Analgesic requirements were less in Group B compared to Group C. Administration of tenoxicam before surgery produced better results suggesting an actual preempitive pain relief. Our data demonstrate that the better postoperative analgesia achieved using epidural bupivacaine and intravenous tenoxicam may reflect a synergistic pharmacologic interection between NSAIDS and local anethetics