Transforming growth factor beta (TGF ß) activity in urine of patients with glomerulonephritis
Braz. j. med. biol. res
;
28(10): 1061-4, Oct. 1995. graf
Artigo
em Inglês
| LILACS
| ID: lil-160996
ABSTRACT
Several lines of experimental evidence have shown that transforming growth factor ß (TGF ß) may play a major role in glomerular diseases, mediating the inflammatory response through glomerulosis. In the present study we evaluated TGF ß activity in occasional urine samples from 7 normal individuals and from 15 patients (10 with focal glomerular sclerosis and 5 with membranous glomerulonephritis) using a CCL-64 mink lung cell growth inhibition assay. Urinary TGF ß activity (reported in relation to urine creatinine concentration, Ucr, mean +/- SD) was higher in patients with focal glomerular sclerosis (x/- 17.32 +/- 15.75 / 10 µg Ucr) and patients with membranous glomerulonephritis (x/- = 17.78 +/- 11.53 / 10 µg Ucr) than in normal individuals (x/- = 0.8 +/- 0.44 / 10 µg Ucr). We also observed that TGF ß activity in urine from patients with focal glomerular...
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Índice:
LILACS (Américas)
Assunto principal:
Glomerulosclerose Segmentar e Focal
/
Fator de Crescimento Transformador beta
/
Glomerulonefrite
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
/
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