Chemical sympathectomy blocks androgen biosynthesis during prepuberty
Braz. j. med. biol. res
;
28(10): 1109-12, Oct. 1995. tab
Artigo
em Inglês
| LILACS
| ID: lil-161003
ABSTRACT
Twenty-one-day old male Wistar rats were injected subcutaneously with guanethidine (GUA) at doses of 5 and 10 mg kg-1 day-1 for 20 days. Animals were sacrificed by decapitation during the prepubertal (41 days of age) and early-pubertal (51 days of age) periods of sexual development. The tests were collected, frozen in liquid N2 and stored at -70oC until determination of testicular progesterone (P), androstenedione (A) and testosterone (T). Higher levels of P (2.18 +/- 0.24 ng/g, control = 1.24 +/- 0.16 ng/g) associated with decreased with decreased levels of androgens (A = 0.26 +/- 0.06 ng/g T = 2.05 +/- 0.19 ng/g; control = 1.86 +/- 0.76 ng/g and 8.48 +/- 1.16 ng/g, respectively) were observed in 10 mg GUA-treated rats of prebubertal age, while only P levels (3.12 +/- 0.51 ng/g, control = 1.73 +/- 0.27 ng/g) were incresead in rats of early pubertal...
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Índice:
LILACS (Américas)
Assunto principal:
Maturidade Sexual
/
Simpatectomia Química
/
Guanetidina
/
Androgênios
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
/
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