Serotonergic vasomotor control in fish gills

RESUMO

Serotonin (5-hydroxytryptamine, 5-HT)-containing neuroepithelial cells (NECs) have been discovered in the gills of fish belonging to different phylogenetic groups, and an additional serotonergic innervation of the gill filaments is present in teleosts. The most apparent effect of serotonin is a bronchial vasoconstriction. For teleosts, it has been postulated that the serotonergic innervation of the proximal portion of the efferent filamental artery (EFA) and adjacent efferent lamellar arterioles (ELA) acts to constrict the vasculature. Thus, as perfusion pressure increases, more lamellae are recruited. In contrast, recent results from rainbow trout show that one precise action of serotonin is a vasoconstriction on the distal portion of the filament vasculature. This may explain why exogenously added serotonin impairs gas exchange in rainbow trout. In addition to constricting the respiratory (arterio-arterial) pathway, injection of serotonin into the Atlantic cod dilates the arterio-venous pathway, diverting blood flow to the arterio-venous pathway. The vasoconstrictory effects of serotonin can be blocked by the 5-HT-receptor antagonist methysergide, whereas the vasodilatory effects cannot.