Let there be light: signal transduction in a mammalian circadian system
Braz. j. med. biol. res
;
29(1): 131-40, Jan. 1996. tab, ilus
Artigo
em Inglês
| LILACS
| ID: lil-161664
RESUMO
Mammalian circadian rhythms are controlled by a biological clock located in the hypothalamic suprachiasmatic nuclei (SCN). This clock is entrained by light through a retinohypothalamic pathway that interacts with the SCN through glutamate neurotransmission. Light pulses during the subjective night induce phase shifts of behavioral rhythms, and also trigger intracellular changes such as the expression of immediate-early genes and activation of transcription factors. In this review, we present a model of the signal transduction pathway leading to photic synchronization of the circadian clock, including the activity of specific second messenger systems, gene expression, and interaction between potential agents capable of producing phase shifts.
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Índice:
LILACS (Américas)
Assunto principal:
Núcleo Supraquiasmático
/
Relógios Biológicos
/
Transdução de Sinais
/
Ritmo Circadiano
/
Luz
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1996
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
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