Antileishmanial agents: synthesis of allopurinol prodrugs for oral administration
Rev. farm. bioquim. Univ. Säo Paulo
;
31(2): 71-8, jul.-dez. 1995. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-162575
ABSTRACT
Synthesis of six prodrugs of allopurinol (4-hydroxypyrazolo-(3,4-d)pyrimidine) is described. These compounds were given orally to male and female BALB/C (sensitive) and C57BL/6 (partially resistant) strains of mice, wich had been previously infected with Leishmania mexicana. The results show that at end of the treatment there was weak regression of lesions confirmed through measurement of nodule diameter in the infected animals
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LILACS (Américas)
Assunto principal:
Pró-Fármacos
/
Leishmaniose
/
Alopurinol
/
Administração Oral
/
Bases de Mannich
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. farm. bioquim. Univ. Säo Paulo
Assunto da revista:
Bioquímica
/
Farmácia
/
Farmacologia
Ano de publicação:
1995
Tipo de documento:
Artigo
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