The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs
Rev. Soc. Bras. Med. Trop
;
28(3): 169-77, jul.-set. 1995. graf, ilus
Artigo
em Inglês
| LILACS
| ID: lil-163731
ABSTRACT
The hemorrhagic syndrome of leptospirosis was studied in guinea pigs. The study correlates hematological, histopathological and immunohistochemical alterations in sixty animals inoculated by the intraperitoneal route with lml of the culture of virulent strain of Leptospira interrogans serovar copenhageni. Leptospirae antigens were detected by immunoperoxidase, chiefly in liver, kidney and heart muscle capillaries. Possible pathogenic mechanisms responsible for hemorrhagic syndrome are discussed with emphasis on toxic and anoxic attacks causing damage to endothelia, platelet depletion and alterations to hemostasia rates prothrombin time [PT], partial thromboplastin time [PT] and Fibrinogen concentrations. The clinical-laboratory picture is compatible with the histopathological observation of disseminated intravascular coagulation [DIC] in most of the guinea pigs from day 4 of infection.
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Índice:
LILACS (Américas)
Assunto principal:
Hemorragia
/
Leptospirose
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
1995
Tipo de documento:
Artigo
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