Substance P does not modify mononuclear cell migration into Ehrlich tumor mass
Braz. j. med. biol. res
; 29(3): 359-62, Mar. 1996. ilus, tab
Article
em En
| LILACS
| ID: lil-163844
Biblioteca responsável:
BR1.1
RESUMO
In the present study, seven adult male mice were inoculated with Ehrlich tumor into the footpad after local substance P release was blocked by neurectomy of the sciatic and saphenous nerves. The contralateral footpad was also inoculated but sham-operated, and used as control. This procedure did not modify the percent of CD4+ (about 1-2 per cent), CD8+ (about 1-3 per cent), macrophages (about 21-22 per cent), lymphocyte B (about 0-1 per cent) and NK (about 1-2 per cent) mononuclear cells present among tumor cells. These data suggest that chemotactic activity of substance P may not be relevant in this situation because the lack of this neurotransmitter (checked by immunohistochemistry) secondary to neurectomy did not change the cell migration profile into tumor mass.
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Índice:
LILACS
Assunto principal:
Linfócitos B
/
Carcinoma de Ehrlich
/
Linfócitos T
/
Substância P
/
Macrófagos
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1996
Tipo de documento:
Article
/
Congress and conference