Progreso de la infección viral en mellizos hijos de madre infectada por el virus de la inmunodeficiencia humana / Progress of viral infection in twins borned from a human immunodeficiency virus infected mother
Rev. méd. Chile
;
123(10): 1189-98, oct. 1995. tab, graf
Artigo
em Espanhol
| LILACS
| ID: lil-164892
ABSTRACT
We studied the evolution of HIV-1 infection and immune response during six years in 2 twins born from an infected mother. The children had a continous progression of the infection, proved by CD4+ cell counts, serum anti-HIV antibodies, cultivable virus and proviral load. Now, both children are on antiviral treatment. The analysis of serum antibodies showed a different immune response in both children. One of them, developed higher levels of antibodies directed against viral proteins and synthetic peptides derived from their aminoacid sequence. In this child, the amount of cultivable virus increased less than in his twin. Nucleotide sequencing of a part of viral genoma, showed that the virus belonged to the B subtype, prevalent in America and Europe. The observed differences in viral sequences suggest a different selective pressure in both twins. This phenomenon could be related to the observed differences in immune response
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Índice:
LILACS (Américas)
Assunto principal:
Infecções por HIV
/
HIV
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
/
Documento de projeto
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