Ultrastructure of voluntary muscle in childhood malnutrition
West Indian med. j
;
44(4): 133-9, Dec. 1995.
Artigo
em Inglês
| LILACS
| ID: lil-165465
ABSTRACT
This paper is part of a study on the electron microscopy of protein-energy malnutrition, using a rapid autopsy protocol. Samples of voluntary muscle, obtained from eight children dying of severe oedematous malnutrition, were fised in glutaraldehyde within 75 minutes of death. Atrophy of myofibres, increased prominence of satellite cells, and segmental necrobiosis were seen by light microscopy. Electron microscopy showed variable depletion of myofibrils. In the most severe case, there was focal absence of myofibrils, also disorganized Z lines, and absent M bands. Residual atrophic myofibrils measured less than 0.1 µm in width. Other specimens showed sarcomere disorganization, mitochondrial swelling, glycogen depletion, sarcoplasmic oedema, and focal contractions of sarcomeres. Though non-specific, rigor may phosphates. These conditions may exist in severe malnutrition, complicated by terminal infection and metabolic disturbances
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Índice:
LILACS (Américas)
Assunto principal:
Desnutrição Proteico-Calórica
/
Músculo Esquelético
Tipo de estudo:
Estudo de etiologia
Limite:
Feminino
/
Humanos
/
Lactente
Idioma:
Inglês
Revista:
West Indian med. j
Assunto da revista:
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
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