Biology of the repair of central nervous system demyelinated lesions
Arq. neuropsiquiatr
;
54(2): 331-4, jun. 1996. ilus
Artigo
em Inglês
| LILACS
| ID: lil-172062
RESUMO
The integrity of myelin sheaths is maintained by oligodendrocytes and Schwann cells respectively in the central nervous system (CNS) and in the peripheral nervous system. The process of demyelination consistin of the withdrawal of myelin sheaths from their axons is a characteristic feature of multiple sclerosis, the most common human demyelinating disease. Many experimental models have been designed to study the biology of demyelination and remyelination (repair of the lost myelin) in the CNS, due to the difficulties in studying human material. In the ethidium bromide (an intercalating gliotoxic drug) model of demyelination, CNS remyelination may be carried out by surviving oligodendrocytes and/or by cells differentiated from the primitive cell lines or either by Schwann cells that invade the CNS. However, some factor such as the age of the experimental anmnals, intensity and time of exposure to the intercalating clinical and the topography of the lesions have marked influente on the repair of the tissue.
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Índice:
LILACS (Américas)
Assunto principal:
Células de Schwann
/
Oligodendroglia
/
Doenças Desmielinizantes
/
Etídio
/
Bainha de Mielina
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Arq. neuropsiquiatr
Assunto da revista:
Neurologia
/
Psiquiatria
Ano de publicação:
1996
Tipo de documento:
Artigo
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