Striatal cytomegalic neurons containing nitric oxide are associated with experimental perinatal asphyxia: implication of cold treatment
Medicina (B.Aires)
;
56(2): 169-72, 1996. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-172301
ABSTRACT
Neuropathological mechanisms triggered by excitatory aminoacids are Known to involve nitric oxide (NO). Neurons containing NO are histochemically reactive to nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), which labels NO synthase in CNS, Sprague-Dawley male rats subjected to perinatal asphyxia (PA) at 37 degreese Celsius, and PA plus 15 degreese Celsius hypothermia were evaluted when 6 months old by NADPH-d histochemical reaction. Computarized image analysis was used for quantification of stained sections. NADPH-d neurons in striatum from subsevere and severe PA showed a significant increment in soma size and dendritic process length versus control and hypothermic treated rats. Post-ischemic damage reurons are therefore involved in NO changes induced by PA that may be prevented by hypothermia treatment.
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Índice:
LILACS (Américas)
Assunto principal:
Asfixia Neonatal
/
Corpo Estriado
/
NADPH Desidrogenase
/
Neurônios
/
Óxido Nítrico
Tipo de estudo:
Fatores de risco
Limite:
Animais
Idioma:
Inglês
Revista:
Medicina (B.Aires)
Assunto da revista:
Medicina
Ano de publicação:
1996
Tipo de documento:
Artigo
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