Seroprevalencia de infección por virus de Epstein Barr en población sana de Santiago de Chile / Seroprevalence of Epstein Barr's virus infection in healthy population at Santiago de Chile

ABSTRACT

To study the rate of infection by Epstein Barr virus (EBV) in Santiago, Chile, the prevalence of antibody to the viral capsid antigen (VCA-IgG) was determined in a group of 663 helthy individuals grouped by age and socioeconomic level (SEL). In addition, several risk factors for infection were studied. VCA-IgG was determined by ELISA. The total prevalence was 76,6 percent. When grouped by age and SEL, 50 percent of the children from low and medium SEL had been already infected by the age two, compared to 5,9 percent in the high SEL (p<0.01). However, by age twenty, 90 percent of the total sample had already specific antibodies to EBV. Age and number of household members were positively associated with the infection. High socioeconomic level represented a delay factor in the acquisition of the virus, (p<0.01). These results show that EBV infection is frequent in Santiago, occurring early in childhood among medium and low SEL. Hence, the classical infectious mononucleosis should be recognized more frequently among adolescents and young adults belonging to high SEL, while the clinical spectrum of associated manifestations different from the typical mononucleosis syndrome should be investigated among those exposed in early age