Retardo puberal e hipogonadismo hipogonadotrófico: diagnóstico diferencial con la prueba de estimulación de prolactina con clorpromazina / Puberal delayed and hypogonadotrophic hypogonadism: differential diagnosis by prolactine stimulation with chlorpromazine test
Rev. méd. Chile
;
123(12): 1477-83, dic. 1995. tab, graf
Artigo
em Espanhol
| LILACS
| ID: lil-173287
ABSTRACT
We studied the changes in plasma levels of prolactin after an intramuscular injection of 0,33 mg/kg chlorpromazine and changes in plasma levels of LH and FSH after the injection of 100 µg iv GnRH in 16 patients with constitutional delayed puberty, 10 patients with hypogonadotrophic hypogonadism and 6 healthy controls. Prolactin response was significantly lower in patients with hypogonadotrophic hypogonadism compared to subjects with constitutional delayed and healthy controls ( prolactin 7.05ñ1.7, 28.9ñ2.7 and 22.0ñ3.4 ng/ml respectively). LH response to GnRH was also lower in patients with hypogonadotrophic hypogonadism, compared to the other groups ( LH 4.3ñ2.5, 13.4ñ5.4 and 17.2ñ4.8 mUI/ml respectively) however, there was a great overlapping of values. No differences between groups were observed in responses of FSH, testosterone and estrogens to GnRH. It is concluded that prolactin response to chlorpromazine is useful in the differential diagnosis of constitutional delayed puberty
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Índice:
LILACS (Américas)
Assunto principal:
Prolactina
/
Puberdade Tardia
/
Clorpromazina
/
Hipogonadismo
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
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