Ethylcellulose as a carrier for controlled-release acetaminophen tablets
P. R. health sci. j
;
11(3): 159-62, dic. 1992.
Artigo
em Inglês
| LILACS
| ID: lil-176765
RESUMO
In this study ethylcellulose was evaluated as a carrier for preparation of prolonged release acetaminophen tablets. Solid dispersions containing three levels of ethylcellulose and acetaminophen (13; 11; 31) were prepared by the solvent method. Also physical mixtures at the same level of ethylcellulose and acetaminophen were prepared. Systems composed of solid dispersion or physical mixture containing the equivalent weight of 50 mg acetaminophen, Emcompress as diluent and 1 per cent magnesium stearate as lubricant were compressed into tablets and tested for dissolution. The dissolution data showed that the drug release decreased as the level of ethylcellulose increased in the solid dispersion formulations. The drug release from tablets prepared with solid dispersion followed the diffusion controlled model for inert porous matrix, while the drug release from tablets prepared with physical mixture followed the first-order kinetic model
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Índice:
LILACS (Américas)
Assunto principal:
Celulose
/
Acetaminofen
Limite:
Humanos
Idioma:
Inglês
Revista:
P. R. health sci. j
Assunto da revista:
Medicina
Ano de publicação:
1992
Tipo de documento:
Artigo
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