Analysis of dystrophin gene deletions in patients from the Mexican population with Duchenne/Becker muscular dystrophy
Arch. med. res
;
24(1): 1-6, mar. 1993. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-176994
ABSTRACT
Forty unrelated Mexican patients with Duchenne/Backer muscular dystrophy were analyzed for intragenic DMD gene deletions, using the multiplex amplification of 15 deletion-prone oxons described by Chamberlain et al. and beggs et al. The percentage of deletions was 52.5 percent, and the majority of them (86.3 percent) were located at the hot spot deletion region which encompasses exons 44 - 55. This frequency is higher than that found in American and European populations. There were no correlations between deletion size, location and clinical severity
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Índice:
LILACS (Américas)
Assunto principal:
População
/
Previsões Demográficas
/
Genética Populacional
/
Doenças Genéticas Inatas
/
Distrofias Musculares
Limite:
Adolescente
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
México
Idioma:
Inglês
Revista:
Arch. med. res
Assunto da revista:
Medicina
Ano de publicação:
1993
Tipo de documento:
Artigo
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