Rat limb allotransplantation: efficacy of subtherapeutic dose combination immunotherapy with cyclosporine (CsA) and RS-61443
Rev. Hosp. Säo Paulo Esc. Paul. Med
;
6(1/2): 15-9, Jan.-Jun. 1995. ilus
Artigo
em Inglês
| LILACS
| ID: lil-179686
RESUMO
The synergic effect of subtherapeutic doses of cyclosporine and RS-61443 was demonstrated in a vascularized rat hindlimb allotransplantation across a strong histocompatibility barrier (Brown-Norway as donors and Fischer 344 as recipients). Low doses of agents in combination minimized the toxicity while increasing the therapeutic efficacy. All animals showed weight loss during the first 15 days posttransplantation and they regained protective sensation within 45 postoperative days. Only 15.38 per cent of the animals presented complications thrombosis, enteritis, autophagia and disorders of unknown etiology.
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Índice:
LILACS (Américas)
Assunto principal:
Ciclosporina
/
Quimioterapia Combinada
/
Extremidades
/
Rejeição de Enxerto
/
Imunossupressores
/
Ácido Micofenólico
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. Hosp. Säo Paulo Esc. Paul. Med
Assunto da revista:
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
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